Genetic Control of Cancer Metastasis

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EDITORIALS Genetic Control of Cancer Metastasis

Cancer is a complex of many types of malignant neoplastic growths, and each cancer of each organ exhibits numerous subsets. Despite this heterogeneity, malignant neoplasms have a uniform characteristic—the ability to invade host tissues and produce metastases. The most fearsome aspect of cancer is metastasis. This fear is well based. There have been great improvements in diagnosis, general pati...

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Cancer metastasis at a glance: A brief view of Breast Cancer Brain Metastasis

Cancer initiation and progression is a challenging scenario through developmental processes, which may be more complicated by occurrence of metastasis. Basically, diverse genetic alterations, including mutations, formation of truncated proteins and related pathways play key roles either in diagnosis or the most influential therapeutic purposes. ...

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Cancer metastasis at a glance: A brief view of Breast Cancer Brain Metastasis

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MAPK signaling control of colon cancer metastasis

Mitogen activated protein kinase (MAPK) signaling pathways convert extracellular signals into specific cellular responses through a cascade of phosphorylation events. Hence, tight regulation of these signaling pathways is essential for normal cell function and deregulation leads to various diseases including tumorigenesis. Three major MAPK families have been found deregulated in cancer: ERK1 an...

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ژورنال

عنوان ژورنال: JNCI Journal of the National Cancer Institute

سال: 1990

ISSN: 0027-8874,1460-2105

DOI: 10.1093/jnci/82.3.166